Of the 3% of Americans affected with autoimmune diseases such as lupus and scleroderma, most are women of child-bearing age. It is known that environmental triggers, including environmental toxicants, play a role in the development of autoimmunity in humans. One such toxicant is the industrial solvent, trichloroethylene (TCE). The influence of TCE exposure during gestation on autoimmune disease in the offspring is undocumented. It is known that developmental exposure to toxicants can often result in more severe health effects than adult exposure. Thus, assessing the effects of TCE during pregnancy for mother and throughout development for the offspring is Dr. Blossom’s primary research interest. Using an autoimmune-prone mouse strain, Dr. Blossom will determine the effects of developmental exposure to occupationally-relevant doses of TCE on the immune systems of pregnant mice and their offspring exposed during gestation, as well as during other critical time points of immune system development. These results will aid in improved assessment of human risks from TCE, as well as other toxicants. Dr. Blossom conducts research as a member of the Arkansas Center for Birth Defects Research and Prevention.
Blossom SJ, Doss JC 2007. Trichloroethylene alters central and peripheral immune function in autoimmune-prone MRL+/+ mice following continuous developmental and early life exposure. Journal of Immunotoxicology 4(2) 129-141.
Blossom SJ, Gilbert KM 2006. Exposure to a metabolite of the environmental toxicant, trichloroethylene, attenuates CD4 + T cell activation-induced cell death by metalloproteinase-dependent FasL shedding. Toxicological Sciences 92(1) 103-114.
Blossom SJ, Pumford NR, Gilbert KM 2004. Activation and attenuation of apoptosis of CD4 + T cells following in vivo exposure to two common environmental toxicants, trichloroacetaldehyde hydrate and trichloroacetic acid. Journal of Autoimmunity 23(3) 211-20.
To find publications by Sarah Blossom, please visit Pubmed Central, a National Institutes of Health-operated site for electronic distribution of life sciences research reports.
Children's University Medical Group (CUMG) : The fetal basis of toxicant-induced autoimmunity
Arkansas Biosciences Institute
Arkansas Center for Birth Defects Research and
13 Children's Way, Mail Slot 512-40
Little Rock, Arkansas 72202